Ethnic Differences in Insulin Granule Exocytosis
نویسندگان
چکیده
منابع مشابه
Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis
Of the four syntaxins specialized for exocytosis, syntaxin (Syn)-2 is the least understood. In this study, we used Syn-2/epimorphin knockout mice to examine the role of Syn-2 in insulin secretory granule (SG) exocytosis. Unexpectedly, Syn-2 knockout mice exhibited paradoxical superior glucose homeostasis resulting from an enhanced insulin secretion. This was confirmed in vitro by pancreatic isl...
متن کاملSecretory granule exocytosis.
Regulated exocytosis of secretory granules or dense-core granules has been examined in many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine, and hemopoietic cells and also in other less well-studied cell types. Secretory granule exocytosis occurs through mechanisms with many aspects in common with synaptic vesicle exocytosis and most likely uses the same bas...
متن کاملDetection of Insulin Granule Exocytosis by an Electrophysiology Method with High Temporal Resolution Reveals Enlarged Insulin Granule Pool in Big3 Knockout Mice Running Title: Big3 Controls Insulin Granule Exocytosis
1 temporal resolution reveals enlarged insulin granule pool in BIG3 knockout mice 2 3 Tao Liu, Hongyu Li, Natalia V. Gounko, Zhuan Zhou, Aimin Xu, Wanjin Hong, 4 Weiping Han 5 6 Singapore Bioimaging Consortium, Institute of Molecular and Cell Biology, and Joint 7 IMB-IMCB Electron Microscopy Suite, Agency for Science, Technology and Research 8 (A*STAR), Singapore; Institute of Molecular Medicin...
متن کاملControl of granule exocytosis in neutrophils.
Neutrophils are granulocytes derived from bone marrow that circulate through the blood and become recruited to tissues during infection or inflammation. They are the most abundant white blood cell and comprise the first line of defence in the innate immune system. However, they are also capable of causing tissue damage in a wide range of diseases. Release of chemotactic signals from inflamed or...
متن کاملSUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans
OBJECTIVE The reversible attachment of small ubiquitin-like modifier (SUMO) proteins controls target localization and function. We examined an acute role for the SUMOylation pathway in downstream events mediating insulin secretion. RESEARCH DESIGN AND METHODS We studied islets and β-cells from mice and human donors, as well as INS-1 832/13 cells. Insulin secretion, intracellular Ca(2+), and β...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2015
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2014.11.581